Externally Funded Research

Summary of Externally Funded Ongoing Research Studies

Principal Investigator : Dr. S. Balasubramanian, Medical Director and Head of the Dept. of Pediatrics, KKCTH
Research Projects : A Phase 4, Randomized, Open-Label Trial to describe the Safety, Tolerability, and Immunogenicity of 13-Valent Pneumococcal Conjugate Vaccine formulated in Multidose Vials when given with routine Pediatric Vaccines in healthy infants in India”.
Funding Agency: Pfizer
Duration: 2018-20
Amount Sanctioned (Rs.): Rs.27,24,600/-
Principal Investigator : Dr. S. Balasubramanian, Medical Director and Head of the Dept. of Pediatrics, KKCTH
Research Projects: A Phase 4, Open-Label, Single Arm, Multicenter Study to describe the Safety of 13-Valent Pneumococcal Conjugate Vaccine in children 6 to 17 years of age in India.
Funding Agency: Pfizer
Duration: 2018-19
Amount Sanctioned (Rs.): Rs.13 lacs
Principal Investigator : Dr. S. Balasubramanian, Medical Director and Head of the Dept. of Pediatrics, KKCTH
Research Projects: A Multicentric,Randomized,Double Blind,Placebo controlled Trial to assess the Efficacy and safety of Saccharomyces Boulardii CNCM-I 3799 Bacillus Subtillis CU-1 combination For treatment of Acute Diarrhoea in Indian children.
Funding Agency: Medclin Research Pvt Ltd-Kolkata
Duration: 2018-19
Amount Sanctioned (Rs.): Rs.4,20,300 /-
Principal Investigator : Dr. S. Balasubramanian, Medical Director and Head of the Dept. of Pediatrics, KKCTH
Research Projects: Hospital based surveillance to assess the distribution and replacement of serotypes of Streptococcus pneumoniae in the nasopharyngeal swab isolates in children aged 1 month to 59 months presenting with fever, and pneumonia attending select hospital-based sentinel sites across India after the introduction of the Pneumococcal Conjugate Vaccine in the Universal Immunization Programme in India.
Funding Agency: ICMR-National Institute of Epidemiology
Duration: 2019-2021
Amount Sanctioned (Rs.): Rs.4 lacs
Principal Investigator : Dr. S. Balasubramanian, Medical Director and Head of the Dept. of Pediatrics, KKCTH
Research Projects: Impact Assessment Study of Rotavirus Vaccine and Intussusception surveillance’
Funding Agency: Welcome Trust Research Laboratory, CMC Vellore /Indian Council for Medical Research (ICMR)
Duration: 2017-2021
Amount Sanctioned (Rs.): Rs 14 lacs
Principal Investigator : Dr. P. Sulochana Putli Bai, Laboratory Director & Head of Microbiology, KKCTH
Research Projects: National Surveillance for Enteric Fever
Funding Agency: Welcome Trust Research Laboratory, CMC Vellore
Duration: 4 years – initiated on September 2017
Amount Sanctioned (Rs.): Rs.30 lacs

Summary of Externally Funded Ongoing Research Studies (2020-2021)

Principal Investigator : Dr. S. Balasubramanian, Medical Director and Head of the Dept. of Pediatrics, KKCTH
Research Projects: A phase II/III, multicenter, randomized, open label, active controlled, clinical study to assess the immunogenicity and safety of tetanus toxoid, diphtheria toxoid, and acellular pertussis (Tdap) vaccine manufactured by Serum institute of India Pvt. Ltd. (SIIPL) in comparison with Boostrix® vaccine of GSK in healthy adults, adolescents and children in India.
Funding Agency: Serum Institute of India.
Duration: Study Approval date: 19 Sept 2018
(1 year study)
Amount Sanctioned (Rs.): Rs.3.5 lacs
Principal Investigator : Dr. S. Balasubramanian, Medical Director and Head of the Dept. of Pediatrics, KKCTH
Research Projects: Sero-prevalence of Anti-Hepatitis A antibodies in four cities from different parts of India.
Funding Agency: Bharati Vidyapeeth (Deemed to be University) Medical College & Hospital, Pune.
Duration: Study Approval date: 28 Nov 2019
(1 year study)
Amount Sanctioned (Rs.): Rs.6 lacs
Principal Investigator : Dr. S. Balasubramanian, Medical Director and Head of the Dept. of Pediatrics, KKCTH
Research Projects: Evalution of Pertussis Disease in Young Infants in India – A Hospital Based Multi-centric Study.
Funding Agency: Medclin Research Pvt.Ltd – Kolkata
Duration: Study Approval date: 28 Nov 2019
(1 year study)
Amount Sanctioned (Rs.): Rs.6 lacs
Principal Investigator : Dr. Chandrakumar N, HOD-Neonatology, KKCTH, Chennai.
Research Projects: Machine Learning based Neonatal Sepsis Platform
Funding Agency: Avyantra Health Technologies, Hyderabad, Telangana
Duration: Study Approval date: 02 July 2019
(1 year study)
Amount Sanctioned (Rs.): Rs.6 lacs
Principal Investigator : Dr. Anand Manoharan, Director Research, (CTMRF)
Research Projects: The Global Research On Antimicrobial Resistance (GRAM) Project.
Funding Agency: Oxford University, UK
Duration: Study Approval date: 02 July 2019
(2 years study)
Amount Sanctioned (Rs.): Rs.5.73 lacs
Principal Investigator : Dr. Anand Manoharan, Director Research, (CTMRF)
Research Projects: Bioinformatics and Molecular Approaches to Characterize the Mechanism of Multidrug Resistance in Salmonella typhi recovered from Children (< 15 years) with Typhoid at a Paediatric Speciality Teaching Hospital
Funding Agency: ICMR, New Delhi
Duration: Study Approval date: 25 Jan 2021
(3 years study)
Amount Sanctioned (Rs.): Rs.9.48 lacs

Summary of Externally Funded Ongoing Research Studies (2021-2022)

Principal Investigator : Dr. S. Balasubramanian, Medical Director, KKCTH
Research Projects: A Case-Control Study to assess the association between Infantile Colic and Atopic Dermatitis, Allergic Rhinitis/Asthma, Childhood Migraine and FAPDs in Indian Children
Funding Agency: Medclin Research Pvt. Ltd., Kolkata
Duration: APR 2021 – AUG 2021
Amount Sanctioned (Rs.): 0.33 LACS
Principal Investigator : Dr. S. Balasubramanian, Medical Director, KKCTH
Research Projects: The Characteristics and Outcomes of Kawasaki Disease and COVID-19 with Cardiac Complications:
A Study from the International Kawasaki Disease Registry (IKDR)
Funding Agency: Johns Hopkins University, USA
Duration: NOV.2021 – OCT.2022
Amount Sanctioned (Rs.): 40 LACS

Summary of Externally Funded Research Studies (April 2022- March 2023)

Principal Investigator : Dr. Sara Chandy, Director (Research), CTMRF.
Research Projects: Acute Undifferentiated Febrile Illness (AUF) seen among children in KKCTH, Chennai: Etiology, Clinical Profile, Diagnosis and Clinical Outcome-A prospective Cohort Study towards development of early diagnostic molecular tools.
Funding Agency: XCyton Diagnostics Pvt Ltd.,Bangalore
Duration: APR. 2022 – MAY 2023
Amount Sanctioned (Rs.): 20 LACS
Principal Investigator : Dr. S. Meena, KKCTH
Research Projects: Genomic Studies To Identify Modifiers Of Beta Thalassemia
Funding Agency: MEDGENOME, Bangalore
Duration: MAY 2022 – APR. 2023
Amount Sanctioned (Rs.): 3.2 LACS
Principal Investigator : Dr. Sara Chandy, Director (Research), CTMRF.
Research Projects: Indo-Russion Project: Identification of immugenic peptide for diagnosis of orthohantavirus infection
Funding Agency: DST
Duration: Feb. 2023 – Jan. 2026
Amount Sanctioned (Rs.): 27 LACS
Principal Investigator : Dr. Anand Manoharan, Director Research, (CTMRF)
Research Projects: The Global Research On Antimicrobial Resistance (GRAM) Project.
Funding Agency: Oxford University, UK

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